Real Madrid kept their nerve to go to the semifinals after the quarterfinal match ended 4–4 on aggregate, necessitating a penalty shootout. The top teams in the Premier League and La Liga continued to inflict damage on one another at the Etihad after an exciting 3-3 draw at the Bernabeu last week.

After Real Madrid took the lead with a goal from Rodrygo after 12 minutes, it looked as though that would be enough for a while. However, with 15 minutes left, Kevin de Bruyne scored to take the match into extra time. After 30 minutes of extra time, neither team was able to find a winner, and Carlo Ancelotti's team prevailed 4-3 in a nail-biting penalty shootout to terminate Man City's European season. After Real Madrid's first penalty attempt was saved by Luka Modric, it was advantage City in the shootout. However, the visitors had a chance when Bernardo Silva and Mateo Kovacic failed.